Rafael Nadal will miss the US Open after the Spaniard ends his 2021 season with a foot injury.
The injury caused the 20-time Grand Slam winner to miss the Cincinnati Masters and the Canadian Open last week.
Defending champion Dominic Thiem and five-time winner Roger Federer have also retired from this year’s US Open.
Nadal, 35, wrote on Instagram: “Honestly, I have been in a lot more pain than I should have with my foot in the past year and I have to take some time off.”
He added: “After discussing it with the team and the family, this decision has been made and I think this is the way to go in trying to recover and recover well.
“I am [determined] doing whatever it takes to get back into the best shape possible, keep competing for the things that really motivate me and the things that I have done for all these years.
“I am convinced that with the recovery of the foot and obviously a very important daily effort, this can be achieved. I will work as hard as possible to make it happen.”
The four-time US Open champion did not compete in Wimbledon or the Olympics in order to rest after the clay court season.
He was injured at Roland Garros in June, where he failed to defend his title for the first time since 2016 in the loss to Novak Djokovic in the semi-finals.
The US Open starts on Monday, August 30, but 2020 champion Thiem will be absent due to a wrist injury and Federer also ended his season as he is preparing for another knee operation.
Federer and Nadal are tied with world number one Novak Djokovic – who will be looking to finish the Grand Slam calendar at Flushing Meadows – for the record 20 Grand Slam titles.